The Nike LeBron 18 Low Sylvester vs. Tweety Space Jam references the rivalry between Looney Tunes characters Sylvester the Cat and Tweety Bird. The shoe features a black and white mesh upper with Yellow Strike and Bright Crimson overlays. Graphic embroidery on the heel, Tune Squad emblems on the tongue, and a red 270 degree Air heel unit with Sylvester’s catchphrase "Sufferin’ Succotash!" printed on the lateral side completes the design.

The Nike LeBron 18 Low Sylvester vs. Tweety Space Jam released in July of 2021 and retailed for $160.