The left foot's tongue and heels of this Kybrid S2 model are decorated with fonts from Bikini Bottom, yellow Swooshes, woodland camouflage, as well as pineapple house designs. The rainbow-styled Nike checks translating the "Be True" offerings on the right side, as well as the plaid sock-liners from the yellow Concepts edition, and a black lacing system complete the design.
The Nike Kybrid S2 Best Of was released on October 30th, 2020. At the time, the retail price was set at $140.