The Nike Dunk Low Siempre Familia draws inspiration from Mictlān, the underworld in Aztec mythology that consists of nine layers, similar to Dante Alighieri's Inferno. Its tonal green reptilian-textural upper and Iguana heel illustration symbolize the inhabitants of the 8th and 9th levels of Mictlān. A decorative multicolor Swoosh displays palettes and graphic styles commonly associated with Día de Muertos, the Mexican Day of the Dead.

The Nike Dunk Low Siempre Familia released in February of 2022 and retailed for $120.